WHAT IS HLA-B27 RELATED UVEITIS?
HLA-B27 related uveitis refers to inflammation of the uvea, a part of the eye, associated with the presence of the HLA-B27 gene. The uvea contains many of the blood vessels that nourish the eye. Inflammation in this area can affect the iris, ciliary body, or the choroid, which are crucial parts of the eye involved in vision.

WHAT IS THE HLA-B27 GENE?
The HLA-B27 gene is a part of our immune system, specifically our human leukocyte antigen (HLA) system. Certain variations of this gene are associated with a higher risk for certain autoimmune diseases, including certain types of uveitis.

WHAT SYSTEMIC DISEASES ARE ASSOCIATED WITH HLA-B27?
1. Ankylosing spondylitis
2. Reactive arthritis
3. Psoriatic arthritis

WHAT ARE THE SYMPTOMS OF HLA-B27 RELATED UVEITIS?
The symptoms can vary, but generally include: eye redness, eye pain, light sensitivity, blurry vision, and dark, floating spots in your vision (floaters). The symptoms can occur in one or both eyes.

HOW IS HLA-B27 RELATED UVEITIS DIAGNOSED?
Diagnosis usually involves a combination of medical history, physical examination, and sometimes specific tests. If uveitis is suspected, your doctor may refer you to an ophthalmologist. The ophthalmologist may perform an eye examination, lab tests, and sometimes imaging studies. The presence of the HLA-B27 gene can be confirmed with a blood test.

IS HLA-B27 RELATED UVEITIS A COMMON CONDITION?
While uveitis itself is not very common, among those with uveitis, HLA-B27 related uveitis is relatively frequent. Uveitis related to HLA-B27 is more common in individuals who already have an HLA-B27 associated disease.

WHAT ARE THE TREATMENT OPTIONS FOR HLA-B27 RELATED UVEITIS?
The goal of treatment is to reduce inflammation, alleviate pain, prevent further tissue damage, and restore any lost vision. Treatment usually involves corticosteroid medications to reduce inflammation. Other treatments, like immune-suppressing medications, may be necessary depending on the severity of the inflammation and the response to corticosteroids.

IS IT HEREDITARY?
Yes, the HLA-B27 gene can be inherited. However, not everyone with the gene will develop uveitis or an associated condition.

CAN IT CAUSE BLINDNESS?
If left untreated, HLA-B27 related uveitis can cause complications that may lead to vision loss. Early detection and treatment are crucial in preserving vision.

IS THERE A CURE FOR HLA-B27 RELATED UVEITIS?
Currently, there is no cure for HLA-B27 related uveitis, but the condition can often be managed effectively with medication to control inflammation and prevent complications.

CAN I LIVE A NORMAL LIFE WITH HLA-B27 RELATED UVEITIS?
Yes, most people with HLA-B27 related uveitis can live normal lives. The key is early detection, regular monitoring, and consistent treatment. Additionally, leading a healthy lifestyle and managing stress can also help in controlling symptoms.

ARE THERE ANY LIFESTYLE CHANGES I CAN MAKE TO MANAGE HLA-B27 RELATED UVEITIS BETTER?
Maintaining a healthy lifestyle is beneficial. This includes a balanced diet, regular exercise, adequate sleep, and stress management. Avoiding smoking and limiting alcohol can also be beneficial.

WILL I NEED TO TAKE MEDICATION FOREVER?
The duration of treatment varies greatly among individuals. Some people may need long-term medication to manage the condition, while others may only need treatment during inflammatory episodes. Your doctor will guide you based on your specific needs.

IS THERE ONGOING RESEARCH ABOUT HLA-B27 RELATED UVEITIS?
Yes, research is ongoing. Scientists are studying the role of HLA-B27 in autoimmune diseases and how this knowledge can be used to develop more effective treatments.

The post HLA-B27 related Uveitis appeared first on Dr Rehman Siddiqui.

Types of Uveitis:

The uvea has three main parts:

1. Iris is the coloured part of the front of the eye, and the central hole in the iris is called the pupil. The iris muscles make the pupil bigger or smaller to control the amount of light entering the eye. Inflammation of the iris is called iritis.
2. The ciliary body is a ring of muscle which lies behind the iris. It helps the eye to focus. Inflammation of ciliary body is called cyclitis. The iris and ciliary body are often inflamed together (iridocyclitis).
3. The choroid lines the inside of the back of the eye and supplies blood for the retina which lies over it. Inflammation of the choroid is called choroitditis. The retina contains light-sensitive cells which form images. Retina is not part of the uvea but is often involved in inflammations of the choroid. The term retinitis is used when the retina is inflamed. Occasionally optic nerve is also inflamed with the retina and it is called neuroretinitis.

Uveitis can be acute (starting suddenly and going away within weeks) or chronic(coming on gradually and lasting for months or more). Acute uveitis is sometimes recurrent. Uveitis can affect one or both eyes, and if both, at the same time or at different times.

Iritis or iridocyclitis usually causes a painful red eye, made worse by bright light, whereas choroiditis is painless. Uveitis can cause the (normally clear) fluids inside the eye to become turbid, or milky. This can blur the vision and can lead to “floaters”. Blurred vision, or gaps in the vision, can occur with any type of uveitis, but this is usually more severe in choroiditis.

If left untreated, uveitis may cause permanent damage to vision.

Complications of Uveitis:

Uveitis sometimes leads to other problems within the eye.

1. Cataracts may occur; the lens inside the eye becomes opaque, and vision will be affected.
2. Glaucoma may also occur, if the pressure inside the eye becomes high; if untreated, this too can damage vision.
3. Uveitis may also cause swelling (macular edema) or scarring of the retina; these will also affect the vision.

Treatment:

The aim of treatment in uveitis is to minimise its effect on vision, and to deal with complications if the need arises.

The treatment of uveitis varies depending on its severity and type. A few specific types of uveitis are caused by infections and need treatment with antibiotics, but most others are treated with steroids. Steroids are drugs that reduce inflammation.

The  most common cause of infectious uveitis in Pakistan is TB

In those with iritis or iridocyclitis the inflammation can usually be controlled with steroid eye drops. In those with very severe iritis, it is necessary to put in steroid drops every hour or two. Those with acute iritis will need treatment only for a few weeks, in gradually decreasing doses. Those with chronic uveitis may need to use drops for much much longer.

Steroid eye drops can not treat choroiditis or retinitis, and for these conditions, steroid treatment may have to be taken by mouth. In very severe cases this is inadequate and additional immuno-suppressive treatment may be necessary.

It is often necessary to give drops to keep the pupil wide open, for several reasons; firstly, it reduces pain in iritis; secondly, it reduces the amount of scarring inside the eye, and helps prevent glaucoma. The drops are inconvenient; they sting when put in and blur the vision, but they are sometimes essential to prevent permanent damage.

If glaucoma develops, treatment will be needed, usually in the form of eye drops. Other medical treatments are sometimes necessary for uveitis. For some complications of uveitis, laser treatment may be necessary. Cataract, if it develops, can only be treated by an operation. Glaucoma may also require an operation.

Uveitis is an extremely variable condition. Every patient and every eye inflammation is different. The information above is intended only to give you a general picture of uveitis. Always ask the doctors and nurses in the clinic if you are unsure of, or need  more  information.

Acknowledgement: Professor Nicholas  Jones.

The post Uveitis appeared first on Dr Rehman Siddiqui.