Vabysmo (Faricimab) for treatment of retinal diseases

Vabysmo (faricimab-svoa) is a medication used to treat certain eye conditions that can lead to vision loss. Administered as an injection directly into the eye by a healthcare professional, it works by targeting specific proteins that cause abnormal blood vessel growth and leakage. This helps improve and maintain your vision.

Which eye conditions does Vabysmo (faricimab) treat?

Vabysmo (faricimab) is prescribed for:

1. Neovascular (Wet) Age-Related Macular Degeneration (AMD): A condition where abnormal blood vessels grow under the retina, leading to vision deterioration.
2. Diabetic Macular Edema (DME): Occurs when high blood sugar levels damage retinal blood vessels, causing fluid buildup and swelling that impair vision.

3. Retinal Vein Occlusion

How does Vabysmo (faricimab) work?

Vabysmo (faricimab) targets and blocks two proteins in the eye:

1. Vascular Endothelial Growth Factor A (VEGF-A): Promotes the growth of abnormal blood vessels.
2. Angiopoietin-2 (Ang-2): Causes blood vessels to become unstable and leaky.

By inhibiting both VEGF-A and Ang-2, the medication reduces abnormal vessel growth and leakage, helping to prevent further vision loss and potentially improving vision.

What makes Vabysmo (faricimab) different from other treatments?

Most other treatments focus only on blocking VEGF-A. Vabysmo (faricimab) is unique because it inhibits both VEGF-A and Ang-2. This dual action provides better control over the underlying causes of certain eye diseases.

What are the benefits of using Vabysmo (faricimab)?

– Improved vision: Many patients notice better vision after starting treatment.
– Fewer injections: Due to its dual mechanism, some patients may require injections less frequently than with other treatments.
– Long-term disease management: By addressing two key proteins, it may offer more effective long-term control of eye conditions.

How is Vabysmo (faricimab) administered?

The medication is given as an injection into the eye:

1. Preparation: Your eye is numbed with drops to reduce discomfort.
2. Injection: A tiny needle delivers the medication into the vitreous, the gel-like substance inside your eye.
3. Aftercare: You might be monitored briefly to ensure there are no immediate side effects.

Will the injection hurt?

Most people experience minimal discomfort. The numbing drops help, but you might feel slight pressure or a brief sting during the injection.

How often will I need injections?

Injection frequency varies:

– Initial phase: More frequent injections to gain control over the condition.
– Maintenance phase: Once stabilized, injections may be scheduled less often.

Your doctor will tailor a treatment plan specific to your needs.

What are the possible side effects?

Common side effects include:

– Eye pain or discomfort: Mild irritation after the injection.
– Floaters: Temporary small spots in your vision.
– Increased eye pressure: Usually temporary and monitored by your doctor.

Serious but rare side effects:

– Infection inside the eye (endophthalmitis): Symptoms include severe pain, redness, or vision changes.
– Retinal detachment: Sudden increase in floaters or flashes of light.

Contact your doctor immediately if you experience severe symptoms.

Can I resume normal activities after the injection?

Yes, but take some precautions:

– Avoid rubbing your eye: Reduces the risk of infection.
– Follow doctor’s instructions: Use prescribed eye drops and attend follow-up appointments.
– Monitor symptoms: Report any unusual changes in vision or discomfort.

How does Vabysmo (faricimab) compare to other anti-VEGF treatments?

Vabysmo (faricimab) offers:

– Dual targeting: Blocks both VEGF-A and Ang-2 for more comprehensive treatment.
– Extended dosing intervals: Some patients may need fewer injections over time.
– Improved outcomes: Studies show significant vision improvements in many patients.

Can Vabysmo (faricimab) cure my eye condition?

While it can significantly improve and manage your condition, it is not a cure. Ongoing treatment and regular monitoring are essential to maintain vision improvements.

What should I expect during treatment?

– Regular appointments: Frequent visits at first, possibly less often later.
– Vision assessments and OCT tests: Your doctor will check your vision and eye health regularly.
– Treatment adjustments: Plans may change based on how you respond.

First Vabysmo (Faricimab-svoa) injection in Pakistan was given by Dr. Rehman Siddiqui in January 2023

How long will I need to continue treatment?

Duration varies by individual. Some may require long-term therapy to maintain vision improvements.

How might my vision change over time with Vabysmo (faricimab)?

Many patients experience:

– Initial improvement: Vision may get better after a few treatments.
– Stabilization: Helps prevent further vision loss.
– Long-term maintenance: Ongoing treatment maintains vision gains.

Are there lifestyle changes that can help my condition?

Yes, consider:

– Healthy diet: Eat leafy greens and foods rich in omega-3 fatty acids.
– Regular exercise: Helps overall health and circulation.
– Quit smoking: Smoking can exacerbate eye conditions.
– Blood sugar control: Crucial for diabetic patients.